Alzheimer's Disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive impairment and behavioral impairment. It is a common type of dementia.In 2018, the International Alzheimer's Association estimated that the global number of dementia patients was about 50 million, and by 2050, it will reach 150 million (if AD is defined based on pathophysiological changes, the estimate is three times higher). AD has become a major issue affecting global public health and social sustainable development.In the clinical research of AD drugs, more and more reliance on central laboratories to provide support for AD pathophysiological changes related to humoral markers. Our scientific team recommends core humoral markers for AD, based on highly sensitive platforms such as MSD, Simoa, etc., to help clinical research of AD drugs.